(246) Risk for Prolonged Opioid Usage after Inflatable Penile Prosthesis, A Global Analysis

Abstract Introduction Urologists are not immune from the opioid epidemic. While narcotics still have a role to play in postoperative pain management, examining individual surgeries, such as inflatable penile prosthesis placement (IPP), identify opportunities limit use should be priority. Objective By querying large, global research network, we sought evaluate impact of narcotic prescription on short term patient outcomes and long-term following IPP placement. Methods TriNetX is collaborative enterprise which collects real-time data almost 89 million patients located 58 healthcare organizations across globe analyzes 20 years back present (2002-2022). We queried for all adult undergoing IPP. The index event was surgery. Cohorts included prescribed oxycodone within 2 days surgery, tramadol or one many frequently oral opioids (oxycodone, hydrocodone, hydromorphone, oxymorphone tramadol) control cohorts were same timeframe. TrinetX identifies prescriptions using RxNorm Concept Unique Identifier, part Unified Medical Language System. also compared taking 6 months 1 day prior surgery against “opioid naive” patients. Our short-term outcome rate return visits Emergency Department (ED) 90 event. diagnosis abuse (ICD-10 F11.1) dependence F11.2) disorder later after evaluated persistent 9 15 consistent with previous literature. Propensity score matching (PSM) performed potential cofounders: age, race, mental behavioral disorders, use. analyses June 28th, 2022. Results There 9702 who received an (Table 1). Patients considered opioid- naive less likely (Relative Risk (RR)=0.51 RR=0.42) at months. postoperatively, specifically, more opioid, oxycodone, (all p<0.05) months, except any (p=0.75). specifically ED visit (RR=1.5 1.3) while postoperatively showed no difference (RR=1.2). significant based naivety, preoperative continue p<0.01). Conclusions has risks prescribing general may increase utilization term. Prescribing partial agonist, tramadol, reduce being non-inferior need emergency department when oxycodone; however, non-opioid regimen preferred maximally risk. Disclosure Any authors act consultant, employee shareholder industry for: Boston Scientific, Coloplast